The Role of TNF-α and Total IgE in Pathogenicity of Iraqi Fuel Stations Workers with Allergic Rhinitis

Allergic Rhinitis (AR) is a chronic immune system inflammation that occurs when the body overreacts to antigens in environment (triggers) and produces variety of symptoms nasal mucosa paranasal sinuses due release many interleukins cytokines. We investigated influence allergen on serum levels TNF-α Total IgE patients with AR their function initiating allergic rhinitis Iraqi petrol station workers Baghdad. One hundred individuals thirty healthy between ages 20 59 were examined. For immunological testing, sandwich ELISA was used evaluate IgE. A complete blood cell count (CBC) for hematological testing. Findings showed positive connection IgE, correlation (r=0.32). The binary logistic regression analysis (BLR) conducted be highly significant (B = 0.02, OR 1.02, p =0.065), viewing an increase one unit increases odds belonging group. had highest area under curve (AUC) compared other markers, value (AUC 0.995), indicating it excellent predictor strong marker AR, sensitivity specificity 94% 100%, respectively. After our research, we reached significance study from clarity role tumor necrosis factor-alpha disease its development coincidence immunoglobulin E considering. It also diagnostic disease.